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KMID : 0377519770020010073
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Chung-Ang Journal of Medicine
1977 Volume.2 No. 1 p.73 ~ p.79
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A Study on Sarles’ Phenomenon of the Rodent Lungfluke, Paragonimus iloktsuenensis
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Yoo Byung-Hoon
Song Chul-Yong
Lee Soon-Hyung
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Abstract
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The experiment was designed to understand the humoral immune response of albino rat host against Paragonimus iloktsuenensis infection by demonstrating the Sarles’ phenomenon. Rats of experimental groups were infected with the metacercariae of P. iloktsuenensis which were isolated from brackish water crab, Sesarma dehaani, and were kept for 3 days, 4 weeks, 10 weeks and 14 weeks of infection period. After the given infection period, live excysted metacercarise of P. iloktsuenensis mixed with the serum of the infected rats were placed on the hole glass slide and incubated at 37℃. These slides were examined microscopically at 24 hours and 48 hours after incubation. Control groups were consisted of 1) uninfected rats, 2) uninfected rats injected intramuscularly with prednisolone 10㎎/㎏ every other day, 3) infected rats injected intramuscularly with prednisolone 10㎎/㎏ every other day. Same procedures as experimental groups were carried on. The results obtained were as follows. 1) Precipitations were formed around the excysted metacercariae in the experimental groups. The precipitations were most prominent around the oral sucker. 2) Sarles’ phenomenon was positive in all the experimental groups of 10 weeks and 14 weeks of infection period. 3) There were no correlations between the number of worms discovered at the infected rats and the intensity of the precipitate formation. 4) Sarles’ phenomenon was negative in all the control groups.
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